MUSCULAR DYSTROPHY

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 Dictionary entry overview: What does muscular dystrophy mean? 

• MUSCULAR DYSTROPHY (noun)
  The noun MUSCULAR DYSTROPHY has 1 sense:

1. any of several hereditary diseases of the muscular system characterized by weakness and wasting of skeletal muscles

  Familiarity information: MUSCULAR DYSTROPHY used as a noun is very rare.

 Dictionary entry details 

• MUSCULAR DYSTROPHY (noun)

Sense 1

Meaning:

Any of several hereditary diseases of the muscular system characterized by weakness and wasting of skeletal muscles

Classified under:

Nouns denoting stable states of affairs

Synonyms:

dystrophy; muscular dystrophy

Hypernyms ("muscular dystrophy" is a kind of...):

congenital disease; genetic abnormality; genetic defect; genetic disease; genetic disorder; hereditary condition; hereditary disease; inherited disease; inherited disorder (a disease or disorder that is inherited genetically)

Hyponyms (each of the following is a kind of "muscular dystrophy"):

Becker muscular dystrophy (a form of muscular dystrophy that sets in in adolescence or adulthood and progresses slowly but will affect all voluntary muscles; characterized by generalized weakness and muscle wasting that affects limb and trunk muscles first; similar to Duchenne's muscular dystrophy but less severe; inheritance is X-linked recessive (carried by females but affecting only males))

distal muscular dystrophy (a form of muscular dystrophy that sets in between 40 and 60 years of age and is characterized by weakness and wasting of the muscles of the hands and forearms and lower legs; inheritance is autosomal dominant)

Duchenne's muscular dystrophy; pseudohypertrophic dystrophy (the most common form of muscular dystrophy; inheritance is X-linked recessive (carried by females but affecting only males))

limb-girdle muscular dystrophy (an autosomal recessive form of muscular dystrophy that appears anywhere from late childhood to middle age; characterized by progressive muscular weakness beginning either in the shoulder or pelvic girdle; usually progresses slowly with cardiopulmonary complications in the later stages)

myotonia atrophica; myotonic dystrophy; myotonic muscular dystrophy; Steinert's disease (a severe form of muscular dystrophy marked by generalized weakness and muscular wasting that affects the face and feet and hands and neck; difficult speech and difficulty with the hands that spreads to the arms and shoulders and legs and hips; the onset can be any time from birth to middle age and the progression is slow; inheritance is autosomal dominant)

oculopharyngeal muscular dystrophy (a form of muscular dystrophy that usually begins between early adulthood and middle age and first affects muscles of the eyelid and throat; progresses slowly with swallowing problems common as the disease progresses; inheritance is autosomal dominant)

 Context examples 

In newition, other SLRP-deficient mice develop a wide array of diseases (osteoporosis, osteoarthritis, muscular dystrophy, Ehlers-Danlos syndrome, and corneal diseases), most of them resulting primarily from an abnormal collagen fibrillogenesis.

(Function of SLRP in Bone Pathway, NCI Thesaurus/BIOCARTA)

An X-linked or autosomal dominant inherited muscular dystrophy.

(Emery-Dreifuss Muscular Dystrophy, NCI Thesaurus)

The researchers want to determine whether the results of their research could become a therapeutic target for rare muscle diseases such as myopathies and muscular dystrophies.

(Researchers Discovered Proteins Essential to Development of Skeletal Muscle, The Titi Tudorancea Bulletin)

This rearrangement is associated with Becker muscular dystrophy.

(IL1RAPL1/DMD Fusion Gene, NCI Thesaurus)

A group of autosomal recessive and less frequently autosomal dominant muscular dystrophies affecting the muscles of the hips and shoulders.

(Limb-Girdle Muscular Dystrophy, NCI Thesaurus)

Representative examples include muscular dystrophy, metabolic myopathies, muscular atrophies, and dermatomyositis.

(Myopathy, NCI Thesaurus)

There is no cure for muscular dystrophy.

(Muscular Dystrophy, NIH: National Institute of Neurological Disorders and Stroke)

Mutation of the gene is associated with facioscapulohumeral muscular dystrophy and a chromosomal translocation t(4;19)(q35;q13) of this gene and the CIC gene is associated with soft tissue sarcoma.

(DUX4 wt Allele, NCI Thesaurus)

Mutation of the gene is associated with limb girdle muscular dystrophy type 2B, distal myopathy with anterior tibial onset, and Miyoshi myopathy.

(DYSF wt Allele, NCI Thesaurus)

In a mouse model of severe muscular dystrophy, in which muscle tissue undergoes repeated cycles of regeneration and degeneration, weekly treatment with a Stat3 inhibitor for a month improved muscle repair.

(Controlling Muscle Repair, NIH)